Cisplatin function

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August undefined, 2024

WebJan 11, 2024 · Cisplatin is a heavy metal compound that is cleared by glomerular filtration and renal tubular secretion. Cisplatin forms DNA crosslinks and adducts through oxidative stress injury. WebCisplatin is a chemotherapeutic drug but induces acute tissue injury. Oleuropein (OLE) is a major phenolic compound and used as a possible natural antioxidant, antimicrobial, and anticancer agent. We hypothesized that antioxidant activity of OLE may decrease cisplatin-induced oxidative stress and prevent to the development of chemotherapeutic ...

Defining cisplatin eligibility in patients with muscle ... - Nature

WebWhat is cisplatin? Cisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other … WebThe repair function of MMR proteins has been reported to be uncoupled from their function in mediating cisplatin-induced cell death [56–58]. Since the primary mechanism of cisplatin involves DNA damage and p53 is also involved in DNA damage signaling, there are many studies that correlate cisplatin and DNA damage and repair with p53 activity ... immediate symptoms of electrical shock

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WebApr 14, 2024 · Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a … WebSep 15, 2024 · Cisplatin is a prescription medicine used to treat the symptoms of cancer in the testicles (Metastatic Testicular Tumors), bladder (Advanced Bladder Cancer) and … WebOct 3, 2024 · Unfortunately, some chemotherapies can also cause strokes, such as methotrexate, cisplatin, imatinib and more. Some agents, such as bevacizumab and sunitinib, intentionally target blood vessels since tumors often create new vessels to send nutrients to the abnormal growth. Unfortunately, side effects can include hemorrhage or … list of software companies in texas

Cellular Responses to Cisplatin-Induced DNA Damage - Hindawi

Chapter 11. Chemotherapy and Kidney Injury - American …

WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. WebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. ... These findings demonstrate that IS promotes malignancy in ... immediate tax refund koreaWebNov 10, 2024 · Many widely-used chemotherapies, like cisplatin, kill tumors by damaging their DNA and inducing programmed cell death. But cells are resilient, and many can continue to function with the help of repair enzymes that simply bypass the damage and continue to replicate the DNA. immediate symptoms of high blood sugar

"Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage … " - Cisplatin function

Cisplatin function

WebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the bloodstream, it … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important.

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WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … WebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, …

WebCisplatin stimulates production of reactive oxygen species and oxidative stress by depleting and inactivating glutathione and other related antioxidants. • Cisplatin induces both … WebSep 15, 2024 · Cisplatin forms irreversible covalent links with DNA, causing cross linking of DNA chains as well as breaks in the DNA chain and missense mutations. The DNA injury …

WebTMEPAI was known to be induced by TGF-β/Smad signaling and have tumorigenic functions that converting TGF-β from tumor suppressor to tumor promoter and inducing epithelial–mesenchymal transition (EMT). ... (IC50) of several anti-cancers: doxorubicin, cisplatin, paclitaxel, and bicalutamide in the presence of TGF-β treatment.Results: KO ... WebCisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and apoptosis, in the other hand semaglutide treatment has normalized dysregulated mitochondrial function and dynamics, …

WebOct 5, 2014 · Exposure to oxidative stress can upset regular biological functions. Cisplatin also induces reactive oxygen species that trigger cell death besides DNA damage. …

WebPurpose: The objective of this study was to develop a pH-dependent calcium carbonate nano-delivery system for the combination therapy of CDDP with oleanolic acid (OA). Methods: A microemulsion method was employed to generate lipid coated cisplatin/oleanolic acid calcium carbonate nanoparticles (CDDP/OA-LCC NPs), and the … immediate symptoms of tbiWebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have … immediate technical writer jobsWebCisplatin is a type of chemotherapy. It destroys quickly dividing cells, such as cancer cells. Find out more about how chemotherapy works How do you have cisplatin? You have cisplatin as a drip into your bloodstream (intravenously). Into your bloodstream You might have treatment through a long plastic tube that goes into a large vein in your chest. immediate teacher feedback researchWebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is … immediate technologyWebApr 14, 2024 · Thus, the aim of this work was to carry out a non-targeted metabolomic approach to study if the apoptotic stimulus (cisplatin or UV light) affects in a different way the metabolites involved in the propagation of apoptosis. Both ABs and their extracellular fluid were analyzed using a reverse-phase liquid chromatography-mass spectrometry setup. list of software engineering internshipsWebJan 17, 2014 · Cisplatin is a widely used and highly effective cytotoxic agent, including for nasopharyngeal carcinoma (NPC). One of the side effects of cisplatin is nephrotoxicity, especially in tubulus.... immediate termination letter to employerWebFeb 16, 2024 · Aluminum reacts with this drug, causing precipitate formation and a loss of potency. Monitoring: Peripheral blood counts should be monitored weekly. Liver function should be monitored periodically. Neurologic examination should be performed regularly. More about cisplatin Further information immediate termination of contract