WebSep 1, 2008 · The cTnT (R141W) was expressed by 1.5- to 2.0-fold that of the endogenous cTnT gene and was showed to assemble in the sarcomere. The transgenic heart exhibited a thinner ventricular wall and an... WebThe transgenic mice were created by the method of microinjection. And they were del crossed with cTnTR141W transgenic mice. The cardiac structure and function were analysed with M-mode echocardiography. Survival data of the experimental mice were recorded. Pathologic changes were observed by light microscopy.
Cardioprotection by Hepc1 in cTnTR141W transgenic mice
WebMSCs significantly decreased chamber dilation and contractile dysfunction in cTnT R141W mouse. MSCs transplanted hearts showed a significant decrease in cardiac apoptosis and their regulation with Akt pathway. Cardiac fibrosis and cytoplasmic vacuolization in the MSCs group was significantly lower. WebDec 24, 2011 · Clinical research has revealed that a missense mutation, R141W, in the strong tropomyosin-binding region of the cTnT gene causes FCDM 3. Recently, we reported that the cTnT R141W transgenic mouse manifests progressive chamber dilation and contractile dysfunction, and has a pathologic phenotype similar to that of human DCM … how to remove onedrive from your pc
Cardioprotection by Hepc1 in cTnT(R141W) transgenic mice
WebFeb 15, 2010 · The cTnTR141W transgenic mice aged 2 months were divided into model group and TMPP group, whereas age-matched … WebThe method cTnTR92Q and cTnTR141W turn gene expression of mouse gene chip and reverse transcriptase PCR and Western blot to detect Meox1 expression changes in hypertrophic cardiomyopathy and dilated cardiomyopathy mouse model of heart. Expression the Western blot the detection Meox1 in time in the wild-type C57BL/6J mouse heart. WebCardioprotection by Hepc1 in cTnTR141W transgenic mice Author: Li Zhang, Dan Lu, Wei Zhang, Xiongzhi Quan, Wei Dong, Yanfeng Xu, Lianfeng Zhang Source: Transgenic … how to remove onedrive link in file explorer