Erythronolide synthase
WebThis entry represents the the beta-ketoacyl synthase region from a number of polyketide synthases including erythronolide synthase and the lovastatin nonaketide chain … WebErythronolide synthase docking The N terminal docking domain found in modular polyketide synthase assumes an alpha-helical structure, wherein two alpha-helices are …
Erythronolide synthase
Did you know?
Weberythronolide B is a biogenetic intermediate in the synthesis of erythromycins A, B, and C and that the erythromycins men- tioned above are closely related biosynthetically. WebIn enzymology, an erythronolide synthase (also 6-Deoxyerythronolide B Synthase or DEBS) is an enzyme that catalyzes the chemical reaction 6 malonyl-CoA + propanoyl …
WebOne of the BLASTp hits of an intestine-derived type I PKS contigs from the symbiotic microbiome of the mangrove shipworm Neoteredo reynei is an erythronolide synthase [53]. ... WebErythronolide synthase. NCBI. National Center for Biotechnology Information. Search. 1PZQ: Structure of fused docking domains from the erythromycin polyketide synthase …
WebIn enzymology, an erythronolide synthase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are malonyl-CoA and propanoyl-CoA, whereas its two products are CoA and 6-deoxyerythronolide b. This enzyme participates in biosynthesis of 12-, 14- and 16-membered macrolides. This enzyme belongs to the … Websynthase, β-ketoacyl reductase, β-ketoacyl dehydratase enzyme-bound 6-deoxy-erythronolide seco acid (linear heptaketide) cyclization upon cleavage from polyketide …
WebErythronolide synthase Imported. Gene names. Name. pks3B Imported. Ordered locus names. ACPL_6148 Imported. Organism names. Organism. Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) Imported. Taxonomic identifier. 134676 NCBI. Taxonomic lineage. Bacteria > Actinobacteria > Micromonosporales > Micromonosporaceae > …
WebJan 23, 2007 · Erythronolide synthase is composed of EryAI, EryAII and EryAIII multimodular (2 modules) polypeptides each coding for a functional synthase subunit which participates in 2 of the six FAS-like elongation steps required for formation of the polyketide. Module 1, 2, 3, 4, 5, and 6 participating in biosynthesis steps 1, 2, 3, 4, 5, and 6, … humana medicare dme auth formWebSep 25, 1992 · Mycocerosic acid synthase (MAS) is a multifunctional protein which catalyzes elongation of n-fatty acyl-CoA with methylamalonyl-CoA as the elongating agent (Rainwater, D. L., and Kolattukudy, P. E. (1985) J. Biol. Chem. 260, 616-623). To understand how the various domains that catalyze the reactions involved in chain … holiday vacations wausau wi alaskaWebSynthesis of Erythronolide A. Erythronolide A (4), with its array of ten stereogenic centers, is the parent of several classic antibiotics, including erythromycin.The key step in the … holiday vacations travel companyWebJun 22, 2024 · Interestingly, although BktB and PKS III orcinol synthase (ORS) are both capable of generating the same polyketide backbone, they share less than 10% protein sequence identity (Extended Data Fig. 3d). humana medicare d medication prior authWebThe antibiotic erythromycin is a complex polyketide of a 14-membered lactone called erythronolide B, which is connected to two deoxysugars called l-mycarose and d … humana medicare diabetic supplies 2019Web8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. … holiday vacations waxxWebIn an uncompleted approach to erythronolide A, Sauve et al. 9 used Ireland's methodology and aimed for spiroketal template 12.1 (Scheme 12) in which the C1–C7 chain was … holiday vacations sioux city