Web17 mrt. 2014 · Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1 α (PGC-1α) was identified as a nuclear receptor coactivator of PPARγ in brown adipose tissue and found to be upregulated in brown adipose tissue and skeletal muscle in … Web4 okt. 2015 · PGC-1α increases energy metabolism and weight loss. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homeostasis, …
PGC-1 α potentiates LXR-mediated autoregulation of the
WebPGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors (NRF-1, 2) and mitochondrial transcription … Web16 mei 2024 · Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α) is a potent transcription factor for mitochondrial function, lipid metabolism, and … inaugurated as president
Long-term T cell fitness and proliferation is driven by AMPK
Web14 jun. 2013 · Abstract Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha (PGC1a) is involved in energy and lipid metabolism, and its loss leads to neurodegenerative changes in the striatum. Here we performed lipidomic analysis on brain extracts from PGC1a mutant and wild-type mice. WebWe investigated whether reduced expression of PGC1A contributes to development of NAFLD using mouse models, primary hepatocytes, and human cell lines. Methods: … PGC-1α is thought to be a master integrator of external signals. It is known to be activated by a host of factors, including: Reactive oxygen species and reactive nitrogen species, both formed endogenously in the cell as by-products of metabolism but upregulated during times of cellular … Meer weergeven Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). … Meer weergeven Recently PPARGC1A has been implicated as a potential therapy for Parkinson's disease conferring protective effects on mitochondrial metabolism. Moreover, … Meer weergeven • MB-3 (drug) • PPARGC1B • Transcription coregulator Meer weergeven • Knutti D, Kralli A (2001). "PGC-1, a versatile coactivator". Trends Endocrinol. Metab. 12 (8): 360–5. doi:10.1016/S1043-2760(01)00457-X. PMID 11551810. S2CID 24230985 Meer weergeven PGC-1α is a super strong gene that contains two promoters, and has 4 alternative splicings. PGC-1α is a transcriptional coactivator that regulates the genes … Meer weergeven PPARGC1A has been shown to interact with: • CREB-binding protein • Estrogen-related receptor alpha Meer weergeven • PPARGC1A protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • NURSA C110 Meer weergeven in all this we are more than conquerors