Kinase profiling services
WebKinase Profiling Services - Luceome Biotechnologies Cell-free KinaseSeeker™ Assays Profile your compound’s selectivity in vitro against a large panel of kinases using our …
Kinase profiling services
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WebThe therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual inhibitors. Herein, we present a series of pyrazolo[3,4-d]pyrimidine derivatives, selected from our in-house … Web26 jan. 2015 · I enjoy to work with new challenges! In my current position as an European Patent Attorney and an authorized Finnish Patent Attorney at Papula, my everyday goal is to help customers to protect their innovations to achieve the best added value of their IPR businesses. I work with start-ups, small companies, universities and …
Web3 dec. 2014 · • 14 years experience in Medication safety, Healthcare Quality improvement, Clinical trial operations (Phase II, III & IV), Pharmacovigilance, Medical Affairs & Clinical development , Medical Information and recognized for medical writing expertise as author and peer reviewer of scientific papers on diverse topics on clinical pharmacology, … WebKinase Assay Services Kinase Panel Screening Cellular Kinase Assays Cellular Kinase Assays BaF3 Cell Proliferation Assay Cellular Phosphorylation Assay NanoBRET TE Intracellular Kinase Assay EGFR Drug Discovery Kinase SubstrateFinder KinaseFinder Customized Kinase Drug Discovery In Vivo Kinase Activity Models Recombinant …
Web1 apr. 2024 · These include medicinal and synthetic chemistry, in vitro pharmacology, safety pharmacology & efficacy, ADME-Tox, cell-based phenotypic assays, and custom … Web24 nov. 2024 · PamGene currently offers two protein kinase profiling chips: a phosphotyrosine kinase (PTK) array and a serine-threonine kinase (STK) array. Each chip contains four identical peptide arrays with either 144 STK or 196 PTK peptide sequences.
WebWith the broadest collections of assays, high-throughput screening and profiling services, and access to customized assays and tools designed to meet your specifications, your …
WebKinases are enzymes that transfer phosphate groups (PO43−) from ATP (adenosine triphosphate) to other specified proteins. They play an extensive role in signal transduction and regulation of complex cellular processes vital to maintain life. They are highly regulated either by themselves, small molecules or protein-protein interactions (PPI). raymond rawls oregonWebSelectScreen Kinase Profiling Service. Profile with our extensive panel of kinases and rapidly receive data for individual assays along the way with Accelerated Data Delivery™ … raymond rayfieldWebKINOMEscan provides ready access to a portfolio of more than 450 high-quality kinase assays, a suite of integrated solutions, user-defined screening parameters and flexible … raymond rawling alsteadWebSelectScreen™ Biochemical Kinase Profiling Service LanthaScreen™ Eu Kinase Binding Assay Screening Protocol and Assay Conditions Revised 07-Jun-2016 Page 3 of 9 LanthaScreen Eu Kinase Binding Assay Conditions Test Compounds The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold serial raymond raymond anthonyWebWith the broadest collections of assays, high-throughput screening and profiling services, and access to customized assays and tools designed to meet your specifications, your … raymond rayWeb7 apr. 2024 · B-cell lymphoma 6 (BCL6) is a transcriptional repressor and oncogenic driver of diffuse large B-cell lymphoma (DLBCL). Here, we report the optimization of our previously reported tricyclic quinolinone series for the inhibition of BCL6. We sought to improve the cellular potency and in vivo exposure of the non-degrading isomer, CCT373567, of our … simplify 208WebAs a drug used to treat imatinib-resistant and -intolerant, chronic and advanced phase chronic myelogenous leukaemia, nilotinib is well characterised as a potent inhibitor of the Abl tyrosine kinase activity of wild-type and imatinib-resistant mutant forms of BCR-Abl. Here we review the profile of nilotinib as a protein kinase inhibitor. raymond ray film